lacZ sequences prevent regulated expression of housekeeping genes
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چکیده
منابع مشابه
lacZ sequences prevent regulated expression of housekeeping genes
In order to dissect the MHC class I H-2K gene regulatory sequences, we p reviously generated transgenic mice containing various H-2K/lacZ fusion genes. However contrary to transgenes where H-2K sequences were fused to other coding sequences, none of the lacZ fusion transgenes was widely ex pressed like H-2K gene. We now show that this silencing also occurs when lacZ is inserted into a larger H-...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2000
ISSN: 0925-4773
DOI: 10.1016/s0925-4773(99)00226-9